In a study published in Nature on January 28, a research team led by Eric H. Xu (Xu Huaqiang) from the Shanghai Institute of ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Primary bile acids are synthesized from cholesterol in the liver, which is transformed to cholic acid (CA) through the classical pathway and chenodeoxycholic acid (CDCA) as an alternative pathway.

A research team has made further progress in the treatment of intestinal inflammation. A study shows that the semi-synthetic bile acid NorUDCA inhibits in the intestine the formation of ...

Chronic cholestasis, defined as the impairment of bile acid formation and/or flow persisting for more than six months, encompasses a broad spectrum of hepatobiliary disorders, both heritable and ...

An international team has shown how the Salmonella protein RamR senses bile acids present in the gut, leading to the activation of a multidrug efflux system that helps bacterial cells to get rid of ...

For the first time, a team of experts from the Technical University of Munich (TUM), RWTH Aachen University, and the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) has demonstrated the ...

Synthesized in the liver, bile acids play diverse roles in digestion and metabolism. However, when their processes are disrupted, disease can occur. Scientists seek advanced technologies to better ...

Bile acid is a liquid substance your liver produces to aid in food digestion. Your body usually releases bile at the correct levels based on the food you eat. But sometimes your body produces too much ...