In cell signaling, calcium is king. The flux of calcium ions across cell membranes regulates cellular activities from muscle contraction to neuron firing to immune cell function. A talk I saw here at ...

In one of the cell's key controls of internal calcium levels, channels at the cell membrane open in response to changes in calcium levels in the endoplasmic reticulum (ER). These plasma membrane ...

Calcium signalling is a pivotal regulatory mechanism in ciliated protozoa, orchestrating a myriad of cellular processes from ciliary beating to membrane trafficking. Recent studies have illuminated ...

Cerebral blood delivery depends on mechanisms such as electrical signaling, which propagates through capillary networks to upstream arterioles to deliver blood, and calcium signaling, which fine-tunes ...

The transition from single-celled organisms to multicellular life was a pivotal moment in evolutionary history, marking the emergence of complex communication systems that allow cells to coordinate ...

Mitochondrial calcium signaling is crucial for energy metabolism and calcium homeostasis, but monitoring it accurately is challenging due to pH fluctuations. Existing GECIs are often sensitive to pH ...

A new method exposes key details of the mechanism behind calcium signaling in prokaryotes for the first time. Working in a Listeria monocytogenes model, researchers from Umeå University (Sweden) led ...

A joint study by the University Medical Center Göttingen (UMG) and the University Hospital Würzburg provides new insights into why heart muscle cells lose their rhythm in atrial fibrillation.

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes, transporters, ...

Tetsuya Hosooka, Yusei Hosokawa, Kaku Matsugi, Masakazu Shinohara, Yoko Senga, Yoshikazu Tamori, Chikako Aoki, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Masashi ...