A new study shows that prolonging cellular energy in brain cells helps transform fleeting experiences into lasting memories.

Calcium signalling is a fundamental process in neurobiology, essential for the regulation of myriad neuronal activities including synaptic transmission, plasticity, and even cell survival. Recent ...

Boosting mitochondrial calcium by inhibiting the LETM1 protein enhances long-term memory formation in flies and mice.

Mitochondrial calcium signaling is crucial for energy metabolism and calcium homeostasis, but monitoring it accurately is challenging due to pH fluctuations. Existing GECIs are often sensitive to pH ...

An international team led by Jaime de Juan-Sanz at the Paris Brain Institute has shown that slightly increasing the metabolic capacity of neurons can enhance long-term memory in both fruit flies and ...

Astrocytes are found throughout the brain. Each astrocyte is in contact with several neurons and more than 100'000 synapses. A new study shows that, at the microscopic level, dozens of synapses from ...

Calcium (Ca 2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, is ...

New work in fruit flies uncovers an electrical trick that allows neurons to compute direction efficiently by juggling multiple signaling mechanisms. These findings could reframe our understanding of ...