Chloride channels and antiport mechanisms are pivotal for maintaining cellular ion homeostasis and regulating physiological processes such as muscle contraction, epithelial fluid transport and ...

Researchers have found that a primitive type of ion channel similar to those found in mammalian nerve cells helps bacteria resist the blast of acid they encounter in the stomach of their hosts. The ...

In the cells of the Arabidopsis plant, exposure to sodium chloride (NaCl) induces the movement (translocation) of the green fluorescent protein (GFP) tagged chloride channel, GFP-AtCLCf, from the ...

Scientists identified a previously unknown chloride ion channel, which they named alkaliphile (Alka), as a taste receptor for alkaline pH. The sense of taste is among the first to come into contact ...

Maintenance of cardiac rhythm and pain sensation require the flow of ions across the membranes of all cells. Ion channels, which facilitate this movement, are protein assemblies that penetrate the ...

Credit: Shutterstock. NMD670 is a first-in-class small molecule inhibitor of the skeletal muscle specific chloride ion channel. The Food and Drug Administration (FDA) has granted Orphan Drug ...

BioRxiv (2023) PubMed PMID: 37546940; PubMed Central PMCID: PMC10402079. The mammalian innate immune system uses cyclic GMP–AMP synthase (cGAS) to synthesize the cyclic dinucleotide 2′,3′-cGAMP during ...

Chloride ion flows that enter the cells play an important role in the duplication of glioblastoma cells, a highly aggressive brain tumor. This is the finding of research recently published in the ...

NMD Pharma Publishes Comprehensive Data Package for NMD670 in Science Translational Medicine ClC-1 is a chloride ion channel specifically expressed in skeletal muscle cells that normally dampens ...

NMD Pharma A/S, a clinical-stage biotech company dedicated to developing novel and improved treatments for patients living with neuromuscular diseases, today announces that Thomas Holm Pedersen, Chief ...