DNA double-strand breaks (DSBs) represent a critical form of damage in which both strands of the DNA helix are severed. If left unrepaired or misrepaired, DSBs can lead to chromosomal translocations, ...

You can always be judged by your scars. This is the idea that sums up what researchers at Spanish National Cancer Research Centre (CNIO) claim is one of the new breakthroughs in basic and biomedical ...

How do we find out which protein works in a particular DNA repair pathway? We know that if a DNA repair gene is mutated, cells become more sensitive to DNA damaging agents. Researchers in the 1960s ...

Cars patched up after a wreck may look fixed—but never run quite as before. The same may hold true for chromatin, according to a study published in Science on November 6. In response to double-strand ...

You can always be judged by your scars. This is the idea that sums up one of the new advances in basic and biomedical research published in the journal Science by the Spanish National Cancer Research ...

An illustration of light purple Cas9 enzyme being guided to light blue DNA against dark blue background. The enzyme Cas9 (top) can cause double-strand breaks in DNA (bottom). Credit: Shutterstock ...

Researchers at Cornell University have developed a safer and more precise way to study how genes function in living tissues ...

Conceptual illustration showing how high transcriptional activity driven by super-enhancers can lead to DNA breaks at oncogenes. When these breaks are repaired inaccurately, they can give rise to ...

Researchers at Cornell University have developed a safer and more precise way to study how genes function in living tissues by refining a recently developed CRISPR-based genetic technique in fruit ...

A study revealed that EXO1 overexpression causes DNA instability in tumors, creating vulnerabilities similar to BRCA-mutant ...