A newly discovered gene switch may help turn chemotherapy-resistant pancreatic cancer into a treatable disease.
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Scientists uncover genetic switch that makes pancreatic cancer chemo-proof
Researchers at Duke-NUS Medical School have identified a molecular switch controlled by the protein GATA6 that determines whether pancreatic cancer cells respond to chemotherapy or become resistant.
Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue [NRAS], ...
Scientists have identified a crucial molecular switch that decides whether pancreatic cancer cells resist chemotherapy or respond to it. The key player, a gene called GATA6, keeps tumours in a more ...
Relationship between aperiodic dynamics and transcriptomic alterations and a neural signature of glioma-induced excitation-inhibition dysregulation. Phase II propensity-matched controlled trial ...
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Drug resistance in pancreatic cancer: Scientists pinpoint major and minor signaling pathways that drive it
Cancer drug resistance is the devastating reason that treatments fail and cancers metastasize, spreading to distant sites seeding new resistant tumors elsewhere in the body. Subscribe to our ...
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