Nature

Fibroblast Growth Factor Receptor Signaling in Cancer

Fibroblast growth factor receptors (FGFRs) are a family of transmembrane tyrosine kinases that orchestrate key cellular processes including proliferation, differentiation, survival and angiogenesis.
Nature

Fibroblast Growth Factor Receptor Alterations in Glioblastoma

Fibroblast growth factor receptors (FGFRs) constitute a family of transmembrane tyrosine kinases that regulate cellular proliferation, differentiation and survival. In glioblastoma, alterations of ...
ascopubs.org

Functional Characterization of Variants of Unknown Significance of Fibroblast Growth Factor Receptors 1-4 and Comparison With AI Model–Based Prediction

Molecular Correlates of Long-Term Response to Bevacizumab in Glioblastoma Recurrent nonkinase domain FGFR VUS variants were collected from the Catalog of Somatic Mutations in Cancer and their ...
ascopubs.org

Prevalence of FGFR2b Protein Overexpression in Advanced Gastric Cancers During Prescreening for the Phase III FORTITUDE-101 Trial

Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer FGFR2b protein ...
Medical Xpress

Multi-scale analysis reveals FGFR1 inhibition as effective strategy against cardiac fibrosis

Through a comprehensive approach combining transcriptomic profiling, histological analysis, and functional validation in organoid and animal models, a research team led by Associate Professor ...
Nasdaq

Anticancer Agent "Tasfygo(R) Tablets 35mg" (Tasurgratinib Succinate) Approved in Japan for Biliary Tract Cancer with FGFR2 Gene Fusions or Rearrangements

TOKYO, Sept 24, 2024 - (JCN Newswire) - - Anticancer Agent "Tasfygo(R) Tablets 35mg" (Tasurgratinib Succinate) Approved in Japan for Biliary Tract Cancer with FGFR2 Gene Fusions or Rearrangements ...