Intraperitoneal therapies (IP) for pancreatic ductal adenocarcinoma (PDAC): A systematic synthesis of hyperthermic intraperitoneal chemotherapy (HIPEC), normothermicintraperitoneal chemotherapy, and ...
A potential target for experimental drugs that block PRMT5—a naturally occurring enzyme some tumors rely more on for survival—has been identified by researchers with the Fralin Biomedical Research ...
The detailed pharmacological and mechanistic characterization of MRTX1719 demonstrates that blocking PRMT5-MTA complex is a rational and differentiated approach to treat cancers harboring MTAP ...
Dual-omic analysis to reveal gene regulatory network of immune landscape in childhood solid tumors and implications for immunotherapy. Phase 1/2 study of TSN222, a novel dual action tumor immune ...
Abbisko Cayman Limited’s subsidiary, Abbisko Therapeutics, has received U.S. FDA clearance for its IND application of ABSK131, a promising small molecule inhibitor aimed at treating advanced solid ...
The gene encoding methylthioadenosine phosphorylase (MTAP) is expressed in normal tissues but 10 to 15% of tumors present deletions of MTAP expression that lead to accumulation of its metabolite ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results