Alagille syndrome, a genetic disease estimated to affect 1 in 30,000 individuals, is caused by mutations in the gene JAG1 in most cases. The mutations affect multiple organs including the liver where ...

Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues. One major characteristic of this condition is abnormalities ...

The biliary system comprises extrahepatic bile ducts, intrahepatic bile ducts, and the gallbladder. The intrahepatic and extrahepatic biliary tree is lined with epithelial cells known as ...