A team of researchers has developed a method that could transform the field of protein engineering. The new approach, called AI-informed Constraints for protein Engineering (AiCE), enables rapid and ...

The ability to evolve proteins with new or improved functions provides powerful applications for the development of selective, high-affinity antibodies, enzymes with new catalytic properties, and the ...

Synthesizing new proteins – the building blocks of biological life – is a scientific field of immense potential, and a newly developed AI model promises to create instructions for new proteins way ...

Researchers at Scripps have created T7-ORACLE, a powerful new tool that speeds up evolution, allowing scientists to design and improve proteins thousands of times faster than nature. Using engineered ...

Schematic of the T7-ORACLE system. The genome is maintained by the non-mutagenic host replisome (gray), while an orthogonal T7 replisome (red) maintains only a dedicated plasmid (OR) at 100,000-fold ...

Proteins are life’s molecular workhorses, doing everything from turning sunlight into food to fighting viruses. They are built from 20 different types of amino acid molecules, so even a small protein ...