Macrophages have a central role in innate immunity, but they also play a part in the coordination of metabolic inflammation linked to metabolic diseases, including obesity and T2D 1,2. As obesity ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 19 (May 10, 2005), pp. 6783-6788 (6 pages) A multiscale simulation of a complex between the lac repressor ...

We have determined the solution structure of the complex between the 'winged-helix' enhancer binding domain of the Mu repressor protein and its cognate DNA site. The structure reveals an unusual use ...

Most of our genome is often written off as “junk DNA”, meaning it doesn’t encode for genes that get made into proteins. This so-called junk consists of accumulated DNA elements like viral DNA that got ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 37 (Sep. 12, 2006), pp. 13676-13681 (6 pages) Metal ion homeostasis is critical to the survival of all ...