Researchers have developed a high-throughput screen methodology to identify compounds affect a key G protein coupled receptor (GPCR) rhodopsin (Rh). GPCRs mediate many important physiological ...

In a new study at University of California, Irvine, researchers have revealed the impact of native lipids on rhodopsin signaling and regeneration, which may usher in a new paradigm for discovery of ...

Researchers have revealed the impact of native lipids on rhodopsin signaling and regeneration, which may usher in a new paradigm for discovery of drugs that target G protein-coupled receptors (GPCRs).

Research in Jastrzebska’s lab focuses on understanding the structure and function of the fundamental visual G protein-coupled receptor (GPCR), rhodopsin, under physiological and pathological ...

Then, on Aug. 4, 2000, structural biologists published the first X-ray structure of a GPCR. That day, an elated Topiol charged into a meeting, the journal article held aloft. “It was all very exciting ...

They are highly diverse in sequence, but contribute the same topological structures. An essential function of GPCR is cell signaling through extracellular signals, such as neurotransmitters and ...