The condition known as von Willebrand disease (vWD) is the result of a reduction in the plasma levels of, or the production of a defective form of, the coagulation factor known as von Willebrand ...

The etiology of thrombotic thrombocytopenic purpura (TTP), a severe blood disorder resulting from increased platelet activation, has been an enigma. The identification of ADAMTS as a protease that ...

In the intact vessel wall (Panel A), endothelial cells hamper the interactions of circulating platelets and their membrane glycoproteins Ibα (GpIbα), nonactivated IIb–IIIa (αIIbβ3), and collagen ...

A 34-year-old woman (gravida 3, para 2) at 16 weeks’ gestation was found to have platelets unable to be quantified because of clumping on routine prenatal blood work, with a visual estimate of 40 ...

The condition known as von Willebrand disease is caused by a deficiency in the quantity or quality of von Willebrand factor (vWF), a key component of the coagulation cascade. Diagnosis starts with ...

Von Willebrand factor (VWF) is a protein crucial to the blood clotting process. If you don’t have enough of this protein, or if it doesn’t work as it’s supposed to, you may have von Willebrand disease ...

For the first time, researchers can quantitatively predict blood flow conditions that likely cause pathological behavior of the human blood protein von Willebrand factor (vWF). Predictions from this ...

Von Willebrand’s disease is the most common inherited bleeding disorder and has an autosomal inheritance pattern. The disease is characterized mainly by mucosa-associated bleeding and bleeding after ...