Imagine a cancer treatment that precisely targets malignant cells, leaving healthy ones untouched. Consider, also, a cancer treatment that corrects abnormal protein synthesis to produce healthy ...

In the fast-evolving field of medical science, a new artificial intelligence model may be about to change the way mRNA-based drugs and vaccines are designed. Developed through a collaboration between ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

Messenger RNAs (mRNAs) possess unique properties making them great therapeutic candidates. However, delivering mRNA drugs to target cells is challenging. Protein nanocages (PNCs) are nanostructures ...

A recent study has reported that a short-acting mRNA therapy can rejuvenate immune function in older mice by compensating for ...

This article explores how challenges such as sequence optimization, immune activation and off-target effects are being addressed to enhance the safety, durability and efficacy of RNA therapeutics.

Both UAP56 and URH49, which form essential complexes for mRNA export, evolved from a common ancestral gene. However, the distinct roles that these complexes play, as well as the structural differences ...

The brain has a powerful ability to keep out blood containing unidentified elements, thanks to a feature known as the blood-brain barrier. Bioengineers believe that they can finally work around this ...

We asked experts about how the technology works, its safety and its potential in medicine. By Nina Agrawal Health Secretary Robert F. Kennedy Jr. has repeatedly questioned the safety of mRNA vaccines ...