Integrin subunits span the cell membrane and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino acids, one of …

By recruiting several proteins that bind actin filaments, the cytoplasmic tails mediate the integrin-cytoskeletal connection, which is essential for most, if not all, integrin mediated functions (see below …

Jan 2, 2023 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational changes, and trafficking.

Aug 23, 2025 · Each integrin is composed of two different protein chains, an alpha (α) and a beta (β) subunit, forming a functional heterodimer. Many alpha and beta subunits exist, and specific …

May 1, 2020 · We focus on more recent advances in conformational regulation and thermodynamics of integrin activation, and on a subset of the key protein-protein interactions within the integrin signaling …

Integrin-ligand combinations can be clustered into four main classes, based on the nature of the molecular interaction. All five αV integrins, two β1 integrins (α5, α8), and αIIbβ3 recognize ligands …

Nov 30, 2023 · The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. Integrins function as adhesion receptors for extracellular ligands and …

4 days ago · The extracellular matrix (ECM) provides critical biochemical and biophysical cues that regulate cell behavior in health and disease. Collagens dominate in abundance and structural …

Integrin adaptor proteins function to link integrin to the actin and microtubule cytoskeletal network, which helps integrins to modulate the regulation and organisation of the cytoskeleton.

The αβ pairings of integrin subunits dictate the specificity of the integrin to a particular ligand, modulate the formation of intracellular adhesion complexes, and regulate downstream signaling.